A 31-year-old man was gored by a bull in the upper leg in the final moments of the run while another man was trampled by the animals, they said in a statement. The remaining three suffered minor cuts and bruises.

The San Fermin festival, immortalized by Ernest Hemingway's 1926 novel "The Sun Also Rises" which is set at the centuries-old the event, attracts tourists from all over the world. It wraps up on July 14.

On the first day of festival 13 people were injured, one seriously, from falls sustained while running through the narrow, twisting cobbled streets of the old town of Pamplona pursued by bulls.

On each day of the festival six bulls are released at 8:00 a.m. (0600 GMT) to run from their corral over an 825-metre (yard) course to the bullring where they face matadors in the afternoon.

Fourteen people have been killed in the bull run since 1911.